The beauty of the World of Darkness setting was that it was so HUGE, I never worried about backing myself into a corner. Any time one of my players called me one of my rulings (over 10 years my campaign became riddled with contradictions), I could always find something to bail me out. ("Ah, yes, you're right, being that vampire is a Tzimisce, he should be infected by the Viccissitude bug... but wait! He's really OLD CLAN Tzimisce. Ta-da!" and many other examples). Since everything was so mysterious, and there was always someone more powerful than the last, the intrigues and conspiracies were going crazy.
(Of course, by the time the Gehenna book came out, they'd pretty much run out of powerhouses. "Your guy is 9th generation? Well this guy is 7th. Then this guy is 4th. That guy's a Methuselah? Bah, here's a bonafide Antidiluvean." By Gehenna, they'd already introduced Caine, who was the most powerful of all. In Gehenna they finally introduced God himself to rain on the characters' parade. At least they didn't give him stats.)
I had finally gotten everything kind of sorted out in my head, and now they want me to re-learn everything in kind of a Bizarro-World-of-Darkness? Eh... maybe, maybe not. I suppose I could just get the WoD sourcebook and stick with the old setting.
Oh, and totally off-topic, but big congrats on the book, Brandon. I'm looking forward to reading it.