Here's the thing, something like "It's Walky" would have been cool, except that he had this years-long story to tell. Far as I could tell, it would have been a really cool story. Had it made sense at all. With only 3-5 panels a day, development moves either so slowly you forget, or it moves too fast and skips lots of detail. It would have been better published a month's worth at a time, I think. (incidentally, most people think he hit his stride with "it's walky" but I think his previous "Roomies" was much superior -- "short packed" has a lot of potential, even if he isn't going as deep with it. I haven't read his new one). MegaTokyo also has this problem. I'm just never sure exactly where it's going -- or more to the point, where exactly it's been.
I agree with sprig. Comics like Bruno the Bandit, Something Positive, or Strip Tease, which have shorter stories, and then move on (they continue to have elements from previous stories, but nothing you have to have read to get into it) work the best for me. Bruno and usually SP have a joke every day and still work toward their goal. This shows some superior writing, I think.
one-offs are funny, but they're much easier to get away from and not read regularly.
What I really hate, though, is when there are 4 or 5 characters that are really similar. Call of Whatever, for example, had at least three characters that were visually very similar, and really weren't that different in personality, so strips got confusing. I hate that. (note, it was still a fun comic, but I kinda had to take on faith that it made sense, if he had ever had any identiy confusion, I would have been totally lost.