I was assuming there would be population control on the multi-generation ship, its basically a flying biodome so you have to keep everything balanced all the time. You'd even want to have backup seeds, water, and all that in case something went wrong. And you'd need more people than that. You'll need enough that at least one person can specialize in medicine, phsycology, engineering, etc. You can't just rely on grabbing the brightest minds of the world because their children and children's children will need to be able to become just as masterful if not moreso. Maybe their children will become really good at space travel and all that, but maybe they will just go insane too. That's the biggest problem, you just never know until its been tried, so something that seems simple like a flying biodome that people grow up and die on might not be as good of an idea as it sounds.
I don't think cryogenics will happen anytime soon, but I guess you never know. It might get invented tomarrow, but it could go the other way just as easy IMO and figure out its not even possible to do with a human without genetic engineering.
heh, I just though of a wierd idea for a spaceship. Instead of it spinning around for artificial gravity, you could fill it up with that breathable water. I'm not sure how hard or easy it is to keep oxigen in that type of water, but assuming you could make some type of plant to do it. You might even have to make the water thicker for it to build up as much resistence as gravity, but it was just an idea.