(1) Would it be possible to design a machine that replicates whatever the "burning" process is in the human stomach, enabling a sort of automated allomancy? This would obviously be kind of worthless for metals like gold and electrum, since a machine doesn't really have a use for knowing what its alternate pasts or futures would be like, but a coppercloud engine would be rather useful, and I have a neat design for an iron- or steel- burning automobile engine... Not to mention that metal repulsion would be the obvious way to take Mistborn spacebound. It seems like it should be possible, since I think it was implied earlier in this thread that even a rock exists to some degree in all three realms, but obviously I don't actually know this.
It's an interesting idea, but I'm fairly certain that in future books that allomancy will be limited to human use, due to its magical origins, as well as inanimate objects not having any amount of preservation to augment to create allomancy. The idea is that allomancy comes from having more than the normal amount of Preservation and while animals and such have Preservation in them (in equal proportions with Ruin) inanimate objects lack that.
(2) Scadrian transhumanism. Would the development of genetic engineering allow for the revival of Mistborns, or is that something that for whatever reason only lerasium can do? (I'm really curious about the chemical structure of lerasium and atium in general - they can be alloyed with normal metals, which implies they have electron shells, but the nucleus almost certainly can't consist of normal protons and neutrons...)
While genetics may contribute to the presence of allomancy, the actual cause of magic is on a more metaphysical level, putting it rather out of reach of normal scientific inquiry.
I've noticed some patterns in Hemalurgy and put together a rather rough table of Hemalurgic Metals.
http://flamepainter.deviantart.com/art/Hemalurgic-Metals-Table-158509497This link goes to the page of DeviantArt where I have it uploaded since I couldn't get it to upload directly here.